Prostate Cancer and the Evolving Role of Biomarkers in Screening and Diagnosis.

Joseph F Rodriguez, Scott E Eggener,

Radiologic clinics of North America, November 30, -0001

The diagnosis and management of prostate cancer have substantially changed over the last 3 decades. Serum prostate-specific antigen (PSA) was adopted for screening in the 1990s after it was found to be a sensitive indicator of disease. Because of a lack of specificity for significant disease, indiscriminate PSA testing led to overdiagnosis and overtreatment. Several biomarkers have been developed that are superior to PSA in stratifying a man’s risk for harboring potentially lethal prostate cancer.

Copyright © 2017 Elsevier Inc. All rights reserved.

Pubmed Link: 29420975

DOI: 10.1016/j.rcl.2017.10.002