Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma.

Fabrizio Tabbò, Alessia Nottegar, Francesco Guerrera, Enrica Migliore, Claudio Luchini, Francesca Maletta, Nicola Veronese, Licia Montagna, Marcello Gaudiano, Filomena Di Giacomo, Pier Luigi Filosso, Luisa Delsedime, Giovannino Ciccone, Aldo Scarpa, Anna Sapino, Alberto Oliaro, Enrico Ruffini, Giorgio Inghirami, Marco Chilosi,

Human pathology, November 30, -0001

Strong prognostic markers able to stratify lung adenocarcinoma (ADC) patients are lacking. We evaluated whether a six-immunohistochemical markers panel (TTF1, SP-A, Napsin A, MUC5AC, CDX2 and CK5), defining the putative neoplastic “cell of origin”, allows to identify prognostic subgroups among lung ADC. We screened a large cohort of ADC specimens (2003-2013) from Torino Institutional Repository identifying: i) marker positivity by immunohistochemistry ii) main morphological appearance by light microscopy, iii) presence of “hot spot” mutations of candidate genes by Sequenom technology. To evaluate possible predictors of survival and time to recurrence, uni- and multivariable-adjusted comparisons were performed. We identified 4 different subgroups: “alveolar”, “bronchiolar”, “mixed” and “null” type. Alveolar-differentiated ADC were more common in young (P=.065), female (P=.083) patients, frequently harboring EGFR mutated (P=.003) tumors with acinar pattern (P

Copyright © 2018. Published by Elsevier Inc.

Pubmed Link: 29409837

DOI: 10.1016/j.humpath.2018.01.017