Circulating D-dimer level correlates with disease characteristics in hepatoblastoma patients.

BinBin Zhang, GongBao Liu, XiangQi Liu, Shan Zheng, Kuiran Dong, Rui Dong,

Medicine, November 30, -0001

Hepatoblastoma (HB) is the most common pediatric liver malignancy, typically affecting children within the first 4 years of life. However, only a few validated blood biomarkers are used in clinical evaluation. The current study explored the clinical application and significance of D-dimer levels in patients with HB. Forty-four patients with HB were included in this retrospective study. D-dimer and plasma fibrinogen levels were examined, and their correlation with other clinical features was analyzed. D-dimer and plasma fibrinogen levels were examined between HB and other benign hepatic tumors. D-dimer levels were significantly associated with high-risk HB features, such as advanced stage and high α-fetoprotein (AFP) levels. Higher D-dimer levels were observed in stage 4 patients compared with stage 1/2/3 patients (P = .028). Higher D-dimer levels were also observed in patients with higher AFP levels before chemotherapy compared with patients with lower AFP levels after chemotherapy (P

Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

Pubmed Link: 29381980

DOI: 10.1097/MD.0000000000008798