Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock.

Alice Cambiaghi, Bernardo Bollen Pinto, Laura Brunelli, Francesca Falcetta, Federico Aletti, Karim Bendjelid, Roberta Pastorelli, Manuela Ferrario,


Scientific reports, August 30, 2017


The early metabolic signatures associated with the progression of septic shock and with responsiveness to therapy can be useful for developing target therapy. The Sequential Organ Failure Assessment (SOFA) score is used for stratifying risk and predicting mortality. This study aimed to verify whether different responses to therapy, assessed as changes in SOFA score at admission (T1, acute phase) and 48 h later (T2, post-resuscitation), are associated with different metabolite patterns. We examined the plasma metabolome of 21 septic shock patients (pts) enrolled in the Shockomics clinical trial (NCT02141607). Patients for which SOFAT2 was >8 and Δ = SOFAT1 - SOFAT2 


Pubmed Link: 28851978

DOI: 10.1038/s41598-017-09619-x