Distinct metabolomic signature in cerebrospinal fluid in early parkinson’s disease.

Jean-Pierre Trezzi, Sara Galozzi, Christian Jaeger, Katalin Barkovits, Kathrin Brockmann, Walter Maetzler, Daniela Berg, Katrin Marcus, Fay Betsou, Karsten Hiller, Brit Mollenhauer,

Movement disorders : official journal of the Movement Disorder Society, August 26, 2017

The purpose of this study was to profile cerebrospinal fluid (CSF) from early-stage PD patients for disease-related metabolic changes and to determine a robust biomarker signature for early-stage PD diagnosis. By applying a non-targeted and mass spectrometry-driven approach, we investigated the CSF metabolome of 44 early-stage sporadic PD patients yet without treatment (DeNoPa cohort). We compared all detected metabolite levels with those measured in CSF of 43 age- and gender-matched healthy controls. After this analysis, we validated the results in an independent PD study cohort (Tübingen cohort). We identified that dehydroascorbic acid levels were significantly lower and fructose, mannose, and threonic acid levels were significantly higher (P 

© 2017 International Parkinson and Movement Disorder Society.

Pubmed Link: 28843022

DOI: 10.1002/mds.27132