Cancer Genomics in Clinical Context.

Lynda Chin, Jennifer A Wargo, Denise J Spring, Hagop Kantarjian, P Andrew Futreal,


Trends in cancer, July 25, 2017


Precision medicine requires appropriate application of genomics in clinical practice. In cancer, we have witnessed practice-changing examples of how genomic knowledge is translated into more tailored and effective therapies. The next opportunity is to embed cancer genomics in clinical context so that patient-centric longitudinal clinical, genomic, and molecular phenotypes can be compiled for adaptive learning between precision medicine research and clinical care with the goal of accelerating clinically-actionable discoveries. We describe here an adaptive learning platform, APOLLO™ (adaptive patient-oriented longitudinal learning and optimization) designed to integrate genomic research in the context of, but not in the path of, routine and investigational clinical care for purposes of enabling data-driven discovery across disciplines such that every patient can contribute to and potentially benefit from research discoveries.

Copyright © 2015 Elsevier Ltd. All rights reserved.


Pubmed Link: 28741560

DOI: 10.1016/j.trecan.2015.07.010