Bioinformatics Data Analysis of Next-Generation Sequencing Data from Heterogeneous Tumor Samples.

Sean R Landman, Tae Hyun Hwang,

Methods in molecular biology (Clifton, N.J.), July 23, 2017

Tumor heterogeneity is a major challenge when it comes to treating cancer and also complicates research aimed at determining genetic sources for tumorigenesis. Leveraging high-throughput sequencing technology has been an effective approach for advancing our understanding of genetic diseases, and this type of data can also be used to better understand and make inferences about tumor heterogeneity. Here we describe the basics of genomics data analysis, as well as analysis pipelines for investigating tumor heterogeneity with next-generation sequencing data.

Pubmed Link: 28735488

DOI: 10.1007/978-1-4939-7142-8_12