The genetic factors contributing to the development of Wilm’s tumor and their clinical utility in its diagnosis and prognosis.

Afsane Bahrami, Marjan Joodi, Mina Maftooh, Gordon A Ferns, Mehrdad Ahmadi, Seyed Mahdi Hassanian, Amir Avan,


Journal of cellular physiology, May 25, 2017


Mutations in the Wilm’s tumor 1 (WT1) gene are associated with a wide spectrum of renal manifestations, ultimately leading to end-stage kidney failure. There is an inadequate understanding of the molecular functions of WT1 in renal development, and this has limited the potential for therapeutic interventions in WT1-related diseases. In this review we discuss the existing data on the genetic and epigenetic abnormalities that have been described in WTs and their potential utility as biomarkers for risk stratification, prediction and prognosis in patients withWTs. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.


Pubmed Link: 28542793

DOI: 10.1002/jcp.26021