Survivin and VEGF as Novel Biomarkers in Diagnosis of Endometriosis.

Milena Acimovic, Snezana Vidakovic, Natasa Milic, Katarina Jeremic, Milos Markovic, Ana Milosevic-Djeric, Gordana Lazovic-Radonjic,


Journal of medical biochemistry, March 30, 2017


The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis. This study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher’s, Student’s t-test or the Mann - Whitney test. There was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p


Pubmed Link: 28356866

DOI: 10.1515/jomb-2015-0005