Effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans in periodontitis patients. A randomized split mouth clinical trial.
Australian dental journal, January 18, 2016
A randomized split-mouth controlled clinical trial was conducted to evaluate the efficacy of photodynamic therapy (PDT) in reducing Aggregatibacter actinomycetemcomitans (Aa) in periodontitis patients. Twenty patients with periodontitis were recruited for the trial. Following random allocation of either quadrants of the selected jaw to test or control treatment, conventional non-surgical periodontal therapy (NSPT) was performed. In addition, the test side received adjunct photodynamic therapy. Probing depth (PD), clinical attachment level (CAL), bleeding on probing (BoP%) and plaque scores (PS%) were recorded at phase 0 (baseline), phase 1 (immediately after NSPT), phase 2 (7 days following NSPT), phase 3 (1 month following NSPT) and phase 4 (3 months following NSPT). Subgingival plaque samples for quantification of Aa by realtime polymerase chain reaction (rt PCR) was done at phase 0, 1, 2, 4. There was a significant clinical improvement at Phase 3 and 4 compared to baseline while BoP reduced significantly only in test group at phase 4. However no difference in the quantification of Aa was detected between the groups. Within limits of the study PDT adjunct to scaling and root planing (SRP) does not lead to quantitative reduction of Aggregatibacter actinomycetemcomitans (Aa) in periodontitis patients. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
Pubmed Link: 26780271