Expression of a hyaluronic acid-binding proteoglycan (versican) in the cynomolgus monkey eye.

Kensuke Tajiri, Eisuke Isizaki, Atsuko Nakaizumi, Takatoshi Kobayashi, Teruyo Kida, Hidehiro Oku, Kimitoshi Nakamura, Hiroko Kuwabara, Tsunehiko Ikeda,

International ophthalmology, January 18, 2016

The expression of versican, a hyaluronic acid (HA)-binding protein, during the development and differentiation of the retina has been reported. In this study, we performed histochemical and immunohistological analysis of HA and versican from the ciliary body to the retina in cynomolgus monkey eyes. Paraffin-embedded sections of cynomolgus monkey eyes, including from the ciliary body to the macular region, were prepared. The distribution of versican and HA was examined by histochemical and immunohistochemical methods. The sites of HA expression and versican expression in the eye specimens were similar. Expression of HA and versican was observed in the peripheral retina and ciliary body, but not from the macular region to the mid-periphery of the retina. Versican was strongly expressed in the ciliary body, particularly in the non-pigmented ciliary epithelium. Expression in the retina from the periphery to posterior pole gradually decreased. Versican is expressed from the ciliary body to the peripheral retina, but this expression decreases toward the posterior pole. This suggests a physiological function for versican in the peripheral retina.

Pubmed Link: 26780096