Pharmacogenetics and anaesthetic drugs: Implications for perioperative practice.

Arash Behrooz,

Annals of medicine and surgery (2012), January 18, 2016

Pharmacogenetics seeks to elucidate the variations in individual’s genetic sequences in order to better understand the differences seen in pharmacokinetics, drug metabolism, and efficacy between patients. This area of research is rapidly accelerating, aided by the use of novel and more economical molecular technologies. A substantial evidence base is being generated with the hopes that in the future it may be used to generate personalised treatment regimens in order to improve patient comfort and safety and reduce incidences of morbidity and mortality. Anaesthetics is an area of particular interest in this field, with previous research leading to better informed practice, specifically with regards to pseudocholinesterase deficiency and malignant hyperthermia. In this review, recent pharmacogenetic data pertaining to anaesthetic drugs will be presented and possible future applications and implications for practice will be discussed.

Pubmed Link: 26779337

Full-text Link: PMC4685230

DOI: 10.1016/j.amsu.2015.11.001