Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study.

Melinda L Jackson, Henry Butt, Michelle Ball, Donald P Lewis, Dorothy Bruck,

Sleep Science (São Paulo, Brazil), January 18, 2016

Chronic Fatigue Syndrome (CFS) is a multisystem illness, which may be associated with imbalances in gut microbiota. This study builds on recent evidence that sleep may be influenced by gut microbiota, by assessing whether changes to microbiota in a clinical population known to have both poor sleep and high rates of colonization with gram-positive faecal Streptococcus, can improve sleep. Twenty-one CFS participants completed a 22- day open label trial. Faecal microbiota analysis was performed at baseline and at the end of the trial. Participants were administered erythromycin 400 mg b.d. for 6 days. Actigraphy and questionnaires were used to monitor sleep, symptoms and mood. Changes in patients who showed a clinically significant change in faecal Streptococcus after treatment (responders; defined as post-therapy distribution

Pubmed Link: 26779319

Full-text Link: PMC4688574

DOI: 10.1016/j.slsci.2015.10.001

DOI: 10.1016/j.slsci.2015.10.001