Compositions And Methods For Immunotherapy
|Document №||Publication date||Filed Date||Application №|
|20160045551||February 18, 2016||August 25, 2015||14/835264|
The present invention provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to immunoresponsive cells bearing antigen receptors, which can be chimeric antigen receptors (CARS), which express introduced ligands for immunomodulatory molecules. In particular embodiments, engineered immunoresponsive cells are antigen-directed and resist immunosuppression and/or have enhances immune-activating properties.