Caprion Biosciences expands tuberculosis to biomarker portfolio

July 26, 2017 – MONTREAL. Caprion Biosciences Inc., a world leading specialty CRO announced the publication of a novel study identifying host blood proteins predictive of early stage (latent) Mycobacterium tuberculosis (Mtb) infection using state-of-the-art ProteoCarta™, a mass spectrometry (MS) and multiple reaction monitoring (MRM-MS) platform.

The new data, recently published in EbioMedicine, expands and strengthens Caprion’s existing portfolio of biomarkers assays for predicting and monitoring of active TB, supporting clients who are developing TB therapeutics and diagnostics. “These findings are very significant and could impact the way we approach treatment, providing a solid basis to accelerate the development of predictive testing” said Eustache Paramithiotis, Vice-President of Discovery at Caprion, who led the study in collaboration Charles Bark, MD and W. Henry Boom, MD from Case Western Reserve University.

In this proteomic study, host proteins expressed differentially between patients uninfected and individuals exposed to M. tuberculosis through contact with family members, which were followed over a period of 12 months. Caprion’s bioinformatic analysis determined multiple biomarker signatures correlating with subsequent development of an immune response recognizing Mtb. These biomarker signatures may demonstrate individuals recently infected by Mtb at high risk for developing active tuberculosis (TB).  

LTBI is a state of persistent immune response resulting from Mtb infection but without evidence of clinically active TB. Current immune-based tests for Mtb infection (LTBI) cannot distinguish recent from remote Mtb infection.  Individuals with recent Mtb infection are at highest risk for developing disease, i.e. TB.  These tests also cannot distinguish LTBI from TB. Worldwide, approximately one-third of the population is latently infected with Mtb, meaning that they do not display any symptoms, chest radiographic abnormalities, or other findings of active TB. Approximately 10% of people with LTBI will develop active TB and are the primary source of TB spreading. Their identification is critical to efforts aimed at controlling TB.

SOURCE Caprion Biosciences