Markers differentiate viral and non-viral causes of systemic inflammation

June 8, 2017 – SEATTLE. Immunexpress, Inc., a molecular diagnostic company with the first FDA cleared host response assay for suspected sepsis patients, today announced the publication, in Scientific Reports, of data demonstrating the ability of a four-biomarker blood signature to discriminate viral and non-viral causes of systemic inflammation in a variety of clinical settings. The manuscript, which is available online, describes the investigation to determine if a blood-based signature could be discovered and show a host systemic response to viral infection.i

Systemic Inflammation (SI) typically presents itself with non-descript clinical signs such as fever and increased respiratory and heart rates, and can be due to a variety of underlying non-infectious or infectious causes including trauma, thermal burns, surgery, ischemia-reperfusion events, and viral or bacterial infections. Establishing the underlying cause of systemic inflammation can be difficult and therefore poses diagnosis, treatment and management challenges for clinicians.ii iii iv v vi

“While current diagnostic methods have improved the capacity to differentiate causes of SI, limitations still exist and point to the need for alternative approaches,” said Richard Brandon, PhD, chief scientific officer of Immunexpress. “Our investigation of biomarker studies indicates that the four-gene signature may aid clinicians in differentiating systemic inflammation due to viral infection, which in critically ill patients may require immediate treatment and initiation of appropriate management procedures.”

The analysis, based on 44 public datasets and two Immunexpress clinical studies in adults and children, identified and validated a four-gene expression signature which includes the Interferon Stimulated Gene (15) (ISG15), Interleukin 16 (IL16), 2’5’-Oligoadenylate Synthetase Like (OASL), and Adhesion G Protein Coupled Receptor E5 (ADGRE5). In each of 13 validation datasets involving humans and other mammals, and all seven Baltimore virus classification groups, the signature demonstrated a meaningful (p